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It has been proposed that non-inferiority margins be taken as ~05 × mean control effect size (that is, 05 × 38 = 190) or as the lower 95% limit of the control effect size (that is, 21) [ 54, 55].

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Siga à risca as orientações médicas e obedeça às instruções de tratamento. Treatment with Zovirax shortened the time to 50% healing; reduced the maximum number of lesions; reduced the median number of vesicles; decreased the median number of residual lesions on day 28; and decreased the proportion of patients with fever, anorexia, and lethargy by day 2.

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